CRYO-ELECTRON MICROSCOPY
We find ourselves gravitating towards the use of cryo-electron microscopy (cryo-EM) as our preferred method for investigating the structure, organization, and function of dynamic molecular complexes. Our techniques encompass a broad range, including cryo-2D crystallography, single particle analysis (SPA), helical reconstruction, and tomography.
These are particularly beneficial for the structural examination of macromolecular assemblies and membrane proteins. This highly specialized field is mastered by a select group of scientists worldwide, which has afforded ua the unique opportunity to collaborate with some of the most innovative minds in the field at various international institutes
Various Types of Bacterial Secretion Systems in Harmful Pathogens
Undeniably, exploring bacterial secretion systems in pathogenic organisms has the potential to make substantial contributions to the understanding of bacterial pathogenesis and host-pathogen interactions. This comprehension forms a critical basis for creating innovative strategies aimed at mitigating infections and curbing the proliferation of antibiotic resistance. A more in-depth examination of the molecular mechanisms that govern secretion systems, as well as their influence on a pathogen's virulence and survival within host organisms, can highlight crucial targets for the development of novel pharmaceutical treatments or therapies.
Vision and Concept of Our Research Team
In essence, our research group's vision and ethos are firmly anchored in a steadfast commitment to propel the field of infectious disease treatment forward. We aim to do this through groundbreaking research and a comprehensive approach that integrates advanced technologies like cryo-EM, cryo-ET, CLEM, and deep learning systems. These tools enable us to delve deeper into the structure and functionality of macromolecular assemblies in infectious bacteria, with a primary goal of identifying novel targets for the development of innovative therapies. This approach is part of our broader ambition to contribute to the global combat against antibiotic resistance.
With access to top-tier resources, including cutting-edge cryo-EM and cryo-ET equipment, and a deep learning system, we are in a unique position to tackle the challenges in the field. This position is further fortified by our highly skilled team and extensive network of collaborators, enabling us to make significant contributions to infectious disease research in the future.